{
 "summary": [
  {
   "claim": "AA = INF axis",
   "rows": [
    {
     "design": "Bulk disease (GSE68801, n=122)",
     "metric": "inflammation\u2191 / hair\u2193",
     "p": 5.2e-13,
     "strong": true
    },
    {
     "design": "Bulk treatment (GSE80342, ruxo 0-24wk)",
     "metric": "infl\u2193 & hair\u2191 in responders",
     "p": 0.0013,
     "strong": true
    },
    {
     "design": "Drug-perturbation (GSE167360, 5 JAK-i)",
     "metric": "INF signature \u2193",
     "p": 0.0196,
     "strong": true
    },
    {
     "design": "Single-cell (GSE212450+GSE316832)",
     "metric": "non-replicating (capture bias)",
     "p": null,
     "strong": false
    }
   ]
  },
  {
   "claim": "AGA = DP Wnt suppression",
   "rows": [
    {
     "design": "Single-cell DP (GSE295410)",
     "metric": "Lef1/Axin2\u2193 +Cxcl12\u2191, 4/4 + reversal",
     "p": 4e-79,
     "strong": true
    },
    {
     "design": "Drug-perturbation (GSE178374, DHT)",
     "metric": "DKK1 \u2191",
     "p": 0.0011,
     "strong": true
    },
    {
     "design": "Bulk disease (GSE90594, n=28)",
     "metric": "hair-keratin \u2193",
     "p": 0.0041,
     "strong": true
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   ]
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  {
   "claim": "Treatment timing",
   "rows": [
    {
     "design": "CT.gov trajectories (THRIVE-AA SALT)",
     "metric": "JAK fit R\u00b2=0.94-0.99",
     "p": null,
     "strong": true
    }
   ]
  },
  {
   "claim": "Causal direction",
   "rows": [
    {
     "design": "340 perturbation\u2192outcome (199 papers)",
     "metric": "89.5% concordant",
     "p": 0.0001,
     "strong": true
    }
   ]
  }
 ],
 "molecular": [
  {
   "t": "AA disease infl\u2191",
   "dz": "AA",
   "p": 1.7e-12
  },
  {
   "t": "AA disease hair\u2193",
   "dz": "AA",
   "p": 5.2e-13
  },
  {
   "t": "AA treat infl\u2193",
   "dz": "AA",
   "p": 0.0013
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  {
   "t": "AA treat hair\u2191",
   "dz": "AA",
   "p": 0.0086
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  {
   "t": "AA JAK-i INF\u2193",
   "dz": "AA",
   "p": 0.0196
  },
  {
   "t": "AGA hair\u2193",
   "dz": "AGA",
   "p": 0.0041
  },
  {
   "t": "AGA DHT\u2192DKK1\u2191",
   "dz": "AGA",
   "p": 0.0011
  },
  {
   "t": "AGA DP Lef1\u2193(sc)",
   "dz": "AGA",
   "p": 4e-79
  }
 ],
 "aga_dp": {
  "conds": [
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    "TP+Ab": 1.6020697355270386
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   "Axin2": {
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    "TP+Ab": 0.3054564595222473
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   "Cxcl12": {
    "Con": 0.09247314929962158,
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    "TP+Ab": 0.15628264844417572
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   "Dkk1": {
    "Con": 0.00035145474248565733,
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    "TP+Ab": 0.0
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 },
 "jak_drugs": {
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  "JAK1i": -1.024,
  "JAK2i": 1.272,
  "JAK3i": -0.807,
  "RUXO": -0.27,
  "Tofa": -0.434
 },
 "aa_sc": {
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    48.5
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    2.6
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  "GSE316832": {
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    0.4,
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   "control": [
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    2.2,
    6.2,
    2.1,
    0.0,
    4.1,
    0.3
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 },
 "gwas": {
  "AGA_cov": 0.25,
  "AA_cov": 0.5625,
  "AGA_in": [
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   "SRD5A2",
   "WNT10A",
   "FGF5"
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  "AA_in": [
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   "CTLA4",
   "IL2",
   "IL21",
   "ULBP3",
   "IKZF4",
   "IL13",
   "CLEC16A",
   "SH2B3"
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 },
 "candidates": [
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   "axis": "AND",
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   "band": "Low (50\u201370)",
   "edges_hi": 0,
   "cohesion": "weak"
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  {
   "gene": "TWIST1",
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   "band": "Low (50\u201370)",
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   "cohesion": "COHERES"
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  {
   "gene": "TWIST2",
   "dz": "AGA",
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   "band": "Confident (70\u201390)",
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   "cohesion": "weak"
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  {
   "gene": "RUNX2",
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   "band": "Low (50\u201370)",
   "edges_hi": 4,
   "cohesion": "COHERES"
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  {
   "gene": "DKK2",
   "dz": "AGA",
   "axis": "Wnt",
   "plddt": 70.5,
   "band": "Confident (70\u201390)",
   "edges_hi": 8,
   "cohesion": "COHERES"
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  {
   "gene": "FZD10",
   "dz": "AGA",
   "axis": "Wnt",
   "plddt": 80.6,
   "band": "Confident (70\u201390)",
   "edges_hi": 7,
   "cohesion": "COHERES"
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  {
   "gene": "PAX1",
   "dz": "AGA",
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   "plddt": 54.6,
   "band": "Low (50\u201370)",
   "edges_hi": 0,
   "cohesion": "isolated"
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  {
   "gene": "EBF1",
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   "band": "Confident (70\u201390)",
   "edges_hi": 0,
   "cohesion": "isolated"
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  {
   "gene": "IRF4",
   "dz": "AGA",
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   "band": "Confident (70\u201390)",
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   "cohesion": "COHERES"
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  {
   "gene": "RORA",
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   "axis": "HFSC",
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   "band": "Confident (70\u201390)",
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   "cohesion": "weak"
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  {
   "gene": "HDAC9",
   "dz": "AGA",
   "axis": "APO",
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   "band": "Low (50\u201370)",
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   "cohesion": "COHERES"
  },
  {
   "gene": "AUTS2",
   "dz": "AGA",
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   "plddt": 41.5,
   "band": "Very low (<50)",
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   "cohesion": "isolated"
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  {
   "gene": "ICOS",
   "dz": "AA",
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   "plddt": 74.0,
   "band": "Confident (70\u201390)",
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   "cohesion": "COHERES"
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  {
   "gene": "CD28",
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   "gene": "IL2RA",
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  {
   "gene": "ERBB3",
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  {
   "gene": "PRDX5",
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   {
    "d": "AGA",
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    "d": "\ubaa8\ub0ad\uc8fc\uae30/HFSC",
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    "n": 3
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 },
 "benchmark": {
  "labels": [
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   "AGA \ubc00\ub3c4%(\uc815\uc0c1\ub300\ube44)"
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  "Halloy": [
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 }
}