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"P:SQLE"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:SREBF1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TAC1"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TNF"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TNFRSF4"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TYR"}, {"type": "in_pathway", "source": "PW:Other", "target": "P:TYRP1"}, {"type": "targeted_by", "source": "P:CASP3", "target": "R:Emricasan (pan-caspase inhibitor, experimental)"}, {"type": "targeted_by", "source": "P:KLRK1", "target": "R:anti-NKG2D (investigational)"}, {"type": "targeted_by", "source": "P:KLRK1", "target": "R:anti-NKG2D antibodies (investigational)"}, {"type": "targeted_by", "source": "P:PPARGC1A", "target": "R:Bezafibrate"}, {"type": "targeted_by", "source": "P:PPARGC1A", "target": "R:Metformin (indirect)"}, {"type": "targeted_by", "source": "P:TAC1", "target": "R:aprepitant / NK1R antagonists (concept)"}, {"type": "targeted_by", "source": "P:TNFRSF4", "target": "R:amlitelimab (anti-OX40L, repurposing concept)"}, {"type": "targeted_by", "source": "P:TNFRSF4", "target": "R:anti-OX40 antibodies (InmaGene, investigational)"}, {"type": "in_pathway", "source": "P:ATF4", "target": "PW:integrated stress response effector"}, {"type": "in_pathway", "source": "P:ATG5", "target": "PW:Macroautophagy"}, {"type": "in_pathway", "source": "PW:Macroautophagy", "target": "P:ATG7"}, {"type": "in_pathway", "source": "P:AXL", "target": "PW:GAS6-AXL/TAM receptor (HFSC activation)"}, {"type": "targeted_by", "source": "P:AXL", "target": "R:AXL agonists (preclinical)"}, {"type": "in_pathway", "source": "P:BCL2L11", "target": "PW:intrinsic apoptosis / immune tolerance"}, {"type": "in_pathway", "source": "P:CALCA", "target": "PW:Sensory neuropeptide restoration of immune privilege"}, {"type": "targeted_by", "source": "P:CALCA", "target": "R:CGRP analogs / capsaicin-induced CGRP release (concept)"}, {"type": "in_pathway", "source": "P:CASP1", "target": "PW:Inflammasome/pyroptosis"}, {"type": "in_pathway", "source": "PW:Inflammasome/pyroptosis", "target": "P:GSDMD"}, {"type": "in_pathway", "source": "P:CD44", "target": "PW:Osteopontin (OPN)-CD44 (HFSC hyperactivation)"}, {"type": "targeted_by", "source": "P:CD44", "target": "R:CD44 agonist peptides (preclinical)"}, {"type": "in_pathway", "source": "PW:Osteopontin (OPN)-CD44 (HFSC hyperactivation)", "target": "P:SPP1"}, {"type": "in_pathway", "source": "P:CD8A", "target": "PW:Cytotoxic immunity"}, {"type": "in_pathway", "source": "PW:Cytotoxic immunity", "target": "P:GZMB"}, {"type": "in_pathway", "source": "P:CDKN1A", "target": "PW:Cell-cycle/apoptosis (p53)"}, {"type": "in_pathway", "source": "P:CDKN2A", "target": "PW:p16-Rb senescence"}, {"type": "targeted_by", "source": "P:CDKN2A", "target": "R:Navitoclax"}, {"type": "targeted_by", "source": "P:CDKN2A", "target": "R:Senolytics (Dasatinib+Quercetin)"}, {"type": "in_pathway", "source": "P:CLEC16A", "target": "PW:autophagy / immune regulation (KIAA0350 locus)"}, {"type": "in_pathway", "source": "P:COL17A1", "target": "PW:hemidesmosome basement-membrane anchorage / HFSC maintenance"}, {"type": "in_pathway", "source": "P:CXCL11", "target": "PW:CXCR3 chemokine axis"}, {"type": "in_pathway", "source": "P:CXXC5", "target": "PW:WNT/beta-catenin (negative feedback via Dishevelled)"}, {"type": "targeted_by", "source": "P:CXXC5", "target": "R:PTD-DBM (peptide, preclinical/early clinical)"}, {"type": "in_pathway", "source": "P:CYP1B1", "target": "PW:xenobiotic/estrogen metabolism (2p22 locus)"}, {"type": "in_pathway", "source": "P:DLX3", "target": "PW:Transcription factor"}, {"type": "in_pathway", "source": "PW:Transcription factor", "target": "P:FOXN1"}, {"type": "in_pathway", "source": "P:EIF2AK4", "target": "PW:integrated stress response (eIF2alpha-ATF4)"}, {"type": "in_pathway", "source": "P:EZH2", "target": "PW:PRC2 / H3K27me3 repression"}, {"type": "targeted_by", "source": "P:EZH2", "target": "R:GSK126 (tool)"}, {"type": "targeted_by", "source": "P:EZH2", "target": "R:Tazemetostat"}, {"type": "in_pathway", "source": "P:F11R", "target": "PW:Tight-junction adhesion / barrier"}, {"type": "in_pathway", "source": "P:F2R", "target": "PW:protease-activated receptor signaling in dermal papilla"}, {"type": "targeted_by", "source": "P:GSDMD", "target": "R:disulfiram (GSDMD inhibitor, investigational)"}, {"type": "in_pathway", "source": "P:GZMA", "target": "PW:cytotoxic T-cell - dermal papilla crosstalk (GZMA-F2R)"}, {"type": "in_pathway", "source": "P:HCAR2", "target": "PW:PGD2-GPR44(CRTH2/PTGDR2) inhibition of hair growth"}, {"type": "targeted_by", "source": "P:HCAR2", "target": "R:setipiprant (Phase 2, AGA)"}, {"type": "in_pathway", "source": "P:HLA-B", "target": "PW:MHC class I antigen presentation (6p21 locus)"}, {"type": "in_pathway", "source": "P:IFNGR1", "target": "PW:Type II interferon"}, {"type": "in_pathway", "source": "P:IKZF4", "target": "PW:FOXP3 transcriptional program / Treg stability"}, {"type": "in_pathway", "source": "P:IL15RA", "target": "PW:Cytokine (common gamma chain)"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL2"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL2RG"}, {"type": "in_pathway", "source": "PW:Cytokine (common gamma chain)", "target": "P:IL7"}, {"type": "targeted_by", "source": "P:IL2", "target": "R:low-dose IL-2 / aldesleukin (investigational)"}, {"type": "in_pathway", "source": "P:IL21", "target": "PW:Tfh/Th17 cytokine signaling (IL2/IL21 locus)"}, {"type": "in_pathway", "source": "P:IL2RB", "target": "PW:Low-dose/PEG-IL-2 -> Treg expansion (tolerance restoration)"}, {"type": "targeted_by", "source": "P:IL2RB", "target": "R:rezpegaldesleukin (Nektar NKTR-358, Phase 2, Fast Track)"}, {"type": "targeted_by", "source": "P:IL2RG", "target": "R:ritlecitinib (via JAK3)"}, {"type": "in_pathway", "source": "P:IL9", "target": "PW:Th9 / mast-cell cytokine signaling (gamma-chain)"}, {"type": "in_pathway", "source": "P:KRT15", "target": "PW:Bulge HFSC intermediate-filament marker"}, {"type": "in_pathway", "source": "P:KRT75", "target": "PW:Keratin/structural"}, {"type": "in_pathway", "source": "P:LDHA", "target": "PW:Glycolytic lactate metabolism"}, {"type": "targeted_by", "source": "P:LDHA", "target": "R:FX11 (experimental)"}, {"type": "targeted_by", "source": "P:LDHA", "target": "R:Oxamate (experimental)"}, {"type": "in_pathway", "source": "P:LGR6", "target": "PW:WNT/R-spondin potentiation"}, {"type": "in_pathway", "source": "P:LRP5", "target": "PW:Wnt/beta-catenin"}, {"type": "in_pathway", "source": "P:LRRC32", "target": "PW:TGF-beta latency / regulatory T-cell function"}, {"type": "in_pathway", "source": "P:MMP9", "target": "PW:extracellular matrix remodeling / fibrosis"}, {"type": "in_pathway", "source": "P:MPC1", "target": "PW:mitochondrial pyruvate import / glycolytic HFSC activation"}, {"type": "in_pathway", "source": "P:MSR1", "target": "PW:M2 macrophage-mediated fibrosis / lipid scavenging"}, {"type": "associated_with", "source": "P:MSR1", "target": "D:lichen planopilaris / CCCA"}, {"type": "in_pathway", "source": "P:NFATC1", "target": "PW:BMP-NFATc1 quiescence control"}, {"type": "targeted_by", "source": "P:NFATC1", "target": "R:Cyclosporine A"}, {"type": "targeted_by", "source": "P:NFATC1", "target": "R:Tacrolimus"}, {"type": "in_pathway", "source": "P:OSM", "target": "PW:OSM/OSMR -> JAK2-STAT5 (HFSC quiescence)"}, {"type": "targeted_by", "source": "P:OSM", "target": "R:OSM/OSMR-targeting antibodies (in development for other indications)"}, {"type": "in_pathway", "source": "P:PADI3", "target": "PW:hair-shaft protein citrullination / inner root sheath integrity"}, {"type": "in_pathway", "source": "P:PTH1R", "target": "PW:GPCR (PTH/PTHrP)"}, {"type": "targeted_by", "source": "P:PTH1R", "target": "R:Abaloparatide / Teriparatide (PTH1R agonists)"}, {"type": "targeted_by", "source": "P:PTH1R", "target": "R:PTH-CBD (collagen-binding PTH agonist)"}, {"type": "in_pathway", "source": "P:S100A3", "target": "PW:PADI3 substrate / cuticle calcium signaling"}, {"type": "in_pathway", "source": "P:SCUBE3", "target": "PW:TGF-beta/SHH activation (dermal papilla anagen signal)"}, {"type": "targeted_by", "source": "P:SCUBE3", "target": "R:AMP-126"}, {"type": "targeted_by", "source": "P:SCUBE3", "target": "R:AMP-303 (Amplifica, Phase 1/2)"}, {"type": "in_pathway", "source": "P:SFRP4", "target": "PW:Wnt antagonism / fibrosis"}, {"type": "in_pathway", "source": "P:SH2B3", "target": "PW:JAK-STAT negative regulation / cytokine signaling"}, {"type": "in_pathway", "source": "P:SOCS1", "target": "PW:JAK-STAT negative feedback"}, {"type": "targeted_by", "source": "P:SPP1", "target": "R:recombinant osteopontin / OPN peptides (preclinical)"}, {"type": "in_pathway", "source": "P:SQSTM1", "target": "PW:Selective autophagy / KEAP1-NRF2 stress"}, {"type": "in_pathway", "source": "P:TCF3", "target": "PW:WNT/TCF stemness repression"}, {"type": "in_pathway", "source": "P:TCF7", "target": "PW:WNT/beta-catenin effector"}, {"type": "in_pathway", "source": "P:TCHH", "target": "PW:PADI3 substrate / inner root sheath cornification"}, {"type": "in_pathway", "source": "P:TLR2", "target": "PW:innate immune sensing of microbiome lipids / NLRP3 priming"}, {"type": "in_pathway", "source": "P:TREM2", "target": "PW:TREM2+ macrophage / Oncostatin M -> JAK-STAT5 (HFSC quiescence)"}, {"type": "targeted_by", "source": "P:TREM2", "target": "R:anti-OSM / OSMR blockade (conceptual)"}, {"type": "in_pathway", "source": "P:TRPS1", "target": "PW:Wnt regulation downstream of YAP inhibition"}, {"type": "in_pathway", "source": "P:TSLP", "target": "PW:epithelial alarmin / IL-7R-TSLPR signaling"}, {"type": "in_pathway", "source": "P:ULBP3", "target": "PW:NKG2D innate cytotoxicity / immune-privilege collapse"}, {"type": "in_pathway", "source": "P:VCAN", "target": "PW:Dermal-papilla ECM / inductivity"}, {"type": "in_pathway", "source": "P:YAP1", "target": "PW:Hippo / mechanotransduction in connective tissue sheath"}, {"type": "in_pathway", "source": "P:ZEB1", "target": "PW:EMT / fibrotic remodeling"}]}