{
  "_description": "IJT 반증 반영 모델 수정(ARM-2 Wnt겹침 overlap) + 독립축 재예측. 시너지는 직교축 쌍에서만 생존; 피나×미녹은 겹침→가법미만(관측 정합).",
  "diagnosis": "미녹시딜 Wnt/β-catenin 활성 → 피나와 W축 겹침 → 원 모델의 독립가정 위반.",
  "revision": "ARM-2에 W-겹침 overlap 도입: e_W=1−(1−e1)(1−e2·overlap), e_D=e2(1−overlap).",
  "overlap_sweep": [
    {
      "overlap": 0.0,
      "R1": 0.386,
      "R2": 0.242,
      "R_combo": 0.657,
      "bliss_expected": 0.535,
      "synergy_excess": 0.122
    },
    {
      "overlap": 0.2,
      "R1": 0.424,
      "R2": 0.333,
      "R_combo": 0.689,
      "bliss_expected": 0.616,
      "synergy_excess": 0.073
    },
    {
      "overlap": 0.4,
      "R1": 0.471,
      "R2": 0.425,
      "R_combo": 0.725,
      "bliss_expected": 0.696,
      "synergy_excess": 0.03
    },
    {
      "overlap": 0.5,
      "R1": 0.499,
      "R2": 0.472,
      "R_combo": 0.746,
      "bliss_expected": 0.735,
      "synergy_excess": 0.011
    },
    {
      "overlap": 0.6,
      "R1": 0.532,
      "R2": 0.519,
      "R_combo": 0.77,
      "bliss_expected": 0.775,
      "synergy_excess": -0.005
    },
    {
      "overlap": 0.8,
      "R1": 0.617,
      "R2": 0.622,
      "R_combo": 0.828,
      "bliss_expected": 0.855,
      "synergy_excess": -0.027
    },
    {
      "overlap": 1.0,
      "R1": 0.744,
      "R2": 0.744,
      "R_combo": 0.909,
      "bliss_expected": 0.934,
      "synergy_excess": -0.025
    }
  ],
  "synergy_crosses_zero_near": 0.6,
  "pair_predictions": {
    "피나 × 미녹시딜(부분겹침)": {
      "overlap": 0.55,
      "R1": 0.515,
      "R2": 0.495,
      "R_combo": 0.758,
      "bliss_expected": 0.755,
      "synergy_excess": 0.003,
      "verdict": "가법"
    },
    "AR차단 × Wnt-agonist(완전중복=둘다 W)": {
      "overlap": 1.0,
      "R1": 0.744,
      "R2": 0.744,
      "R_combo": 0.909,
      "bliss_expected": 0.934,
      "synergy_excess": -0.025,
      "verdict": "가법미만"
    },
    "W축 약물 × 순수 D약물(직교, Wnt무관)": {
      "overlap": 0.0,
      "R1": 0.386,
      "R2": 0.242,
      "R_combo": 0.657,
      "bliss_expected": 0.535,
      "synergy_excess": 0.122,
      "verdict": "초가법(synergy)"
    }
  },
  "new_falsifiable_prediction": "초가법 시너지는 *기전적으로 직교(한쪽 Wnt 무관 D-제제)* 인 쌍에서만 발생. 피나×미녹 같은 부분겹침 쌍은 가법미만(IJT 2023 관측과 일치).",
  "honest": "overlap은 반증이 가르쳐준 모델 수정(자유예측 아님). 새 예측은 진짜 직교 약물쌍 전향 검정 필요. 미녹 Wnt활성은 문헌 근거(예: 미녹시딜→DP β-catenin↑)."
}