1 line
2.3 KiB
JSON
1 line
2.3 KiB
JSON
{"n_records": 338, "n_testable": 57, "accuracy_before": 0.86, "accuracy_after": 0.86, "trajectory": [0.86], "overrides": {}, "mismatches_after": [{"gene": "BCL2", "kind": "gene_gain", "obs": "inhibit", "pred": "promote", "paper": "Overexpression of Bcl-2 Protects from Ultraviolet ", "quote": "Compared to WT mice, the K14/Bcl-2 mice displayed macroscopically visible hair loss 2 days earlier (not shown), and the wave of alopecia pro"}, {"gene": "CXCL12", "kind": "gene_gain", "obs": "promote", "pred": "inhibit", "paper": "Impact of SDF-1 and AMD3100 on Hair Follicle Dynam", "quote": "SDF-1 promotes hair growth in chronic stress mice by activating the PI3K/Akt and JAK/STAT pathways, an effect reversible by AMD3100."}, {"gene": "CXCR4", "kind": "gene_loss", "obs": "inhibit", "pred": "promote", "paper": "Impact of SDF-1 and AMD3100 on Hair Follicle Dynam", "quote": "Following subcutaneous injection of SDF-1 or treatment with AMD3100 to block the binding of SDF-1 to CXCR4... Blocking the binding of SDF-1 "}, {"gene": "CXCL12", "kind": "gene_loss", "obs": "inhibit", "pred": "promote", "paper": "Impact of SDF-1 and AMD3100 on Hair Follicle Dynam", "quote": "Silencing SDF-1 through siRNA-mediated inhibition reduced cell proliferation and migration abilities."}, {"gene": "MSX2", "kind": "gene_loss", "obs": "inhibit", "pred": "promote", "paper": "‘Cyclic alopecia’ in Msx2 mutants defects in hair ", "quote": "Msx2-deficient mice exhibit progressive hair loss, starting at P14 and followed by successive cycles of wavelike regrowth and loss."}, {"gene": "EGFR", "kind": "gene_loss", "obs": "promote", "pred": "inhibit", "paper": "Role for the Epidermal Growth Factor Receptor in C", "quote": "Cyclophosphamide treatment of control mice resulted in alopecia while Egfr mutant skin was resistant to cyclophosphamide-induced alopecia."}, {"gene": "IGF1", "kind": "gene_loss", "obs": "promote", "pred": "inhibit", "paper": "The AR miR-221 IGF-1 pathway mediates the pathogen", "quote": "Hair follicle organ culture experiments showed that IGF-1 could rescue the miR-221-mediated suppression of hair growth and induction of anag"}, {"gene": "CD44", "kind": "gene_loss", "obs": "promote", "pred": "inhibit", "paper": "The C3H HeJ mouse and DEBR rat models for alopecia", "quote": "These data showed that anti-CD44v10 inhibited the onset of AA in AA graft induced C3H/HeJ mice."}]} |