alopecia/data/protein_xvalidation.json

{"axes": {"Wnt": {"n_genes": 15, "ppi": {"n_genes": 15, "edges": 63, "expected": 3, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Canonical Wnt signaling pathway", "fdr": 2.28e-18, "category": "Process"}, "top_terms": [{"term": "Canonical Wnt signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Wnt signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Positive regulation of Wnt signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of Wnt signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Anterior/posterior pattern specification", "fdr": 0.0, "cat": "Process"}]}}, "AND": {"n_genes": 6, "ppi": {"n_genes": 6, "edges": 12, "expected": 0, "p_value": 2.22e-16}, "functional": {"label_matched": true, "matched": {"term": "Androgen metabolic process", "fdr": 1.53e-06, "category": "Process"}, "top_terms": [{"term": "Metabolism of steroid hormones", "fdr": 0.0, "cat": "RCTM"}, {"term": "Steroid hormone biosynthesis", "fdr": 1e-06, "cat": "KEGG"}, {"term": "Androgen metabolic process", "fdr": 2e-06, "cat": "Process"}, {"term": "Steroid hormone biosynthetic process", "fdr": 2e-06, "cat": "Process"}, {"term": "Genitalia development", "fdr": 2e-06, "cat": "Process"}]}}, "DP": {"n_genes": 23, "ppi": {"n_genes": 23, "edges": 112, "expected": 36, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Cellular response to growth factor stimulus", "fdr": 2.27e-08, "category": "Process"}, "top_terms": [{"term": "Positive regulation of phosphorylation", "fdr": 0.0, "cat": "Process"}, {"term": "Positive regulation of protein phosphorylation", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of cell migration", "fdr": 0.0, "cat": "Process"}, {"term": "Positive regulation of cell migration", "fdr": 0.0, "cat": "Process"}, {"term": "Enzyme-linked receptor protein signaling pathway", "fdr": 0.0, "cat": "Process"}]}}, "APO": {"n_genes": 35, "ppi": {"n_genes": 35, "edges": 188, "expected": 63, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Positive regulation of programmed cell death", "fdr": 2.7e-12, "category": "Process"}, "top_terms": [{"term": "Positive regulation of programmed cell death", "fdr": 0.0, "cat": "Process"}, {"term": "Apoptotic process", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of programmed cell death", "fdr": 0.0, "cat": "Process"}, {"term": "Positive regulation of apoptotic process", "fdr": 0.0, "cat": "Process"}, {"term": "Negative regulation of cell population proliferation", "fdr": 0.0, "cat": "Process"}]}}, "INF": {"n_genes": 52, "ppi": {"n_genes": 52, "edges": 629, "expected": 89, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Immune system process", "fdr": 1.19e-35, "category": "Process"}, "top_terms": [{"term": "Immune system process", "fdr": 0.0, "cat": "Process"}, {"term": "Immune response", "fdr": 0.0, "cat": "Process"}, {"term": "Cytokine-mediated signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Cellular response to cytokine stimulus", "fdr": 0.0, "cat": "Process"}, {"term": "Cell surface receptor signaling pathway", "fdr": 0.0, "cat": "Process"}]}}, "HFSC": {"n_genes": 16, "ppi": {"n_genes": 16, "edges": 36, "expected": 10, "p_value": 1.08e-10}, "functional": {"label_matched": true, "matched": {"term": "Tissue development", "fdr": 0.00011, "category": "Process"}, "top_terms": [{"term": "Hair follicle development: cytodifferentiation - part 3 of 3", "fdr": 6e-06, "cat": "WikiPathways"}, {"term": "Tissue development", "fdr": 0.00011, "cat": "Process"}, {"term": "Reproductive structure development", "fdr": 0.00021, "cat": "Process"}, {"term": "Prostate gland growth", "fdr": 0.00078, "cat": "Process"}, {"term": "Developmental process involved in reproduction", "fdr": 0.0015, "cat": "Process"}]}}, "SHH": {"n_genes": 3, "ppi": {"n_genes": 3, "edges": 3, "expected": 0, "p_value": 0.00097}, "functional": {"label_matched": true, "matched": {"term": "Smoothened signaling pathway", "fdr": 0.00063, "category": "Process"}, "top_terms": [{"term": "EDA signaling in hair follicle development", "fdr": 0.0, "cat": "WikiPathways"}, {"term": "Hedgehog signaling pathway", "fdr": 0.0, "cat": "WikiPathways"}, {"term": "Hair follicle development: organogenesis - part 2 of 3", "fdr": 1e-06, "cat": "WikiPathways"}, {"term": "Hedgehog signaling pathway", "fdr": 2e-06, "cat": "WikiPathways"}, {"term": "Hedgehog signaling pathway", "fdr": 5e-06, "cat": "KEGG"}]}}, "BMP": {"n_genes": 7, "ppi": {"n_genes": 7, "edges": 11, "expected": 1, "p_value": 2.68e-11}, "functional": {"label_matched": true, "matched": {"term": "BMP signaling pathway involved in heart development", "fdr": 2.88e-08, "category": "Process"}, "top_terms": [{"term": "BMP signaling pathway involved in heart development", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of osteoblast differentiation", "fdr": 1e-06, "cat": "Process"}, {"term": "Endocardial cushion development", "fdr": 5e-06, "cat": "Process"}, {"term": "Positive regulation of osteoblast differentiation", "fdr": 1.8e-05, "cat": "Process"}, {"term": "Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway", "fdr": 3e-05, "cat": "Process"}]}}}, "diseases": {"AA": {"n_genes": 60, "ppi": {"n_genes": 60, "edges": 711, "expected": 124, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Immune system process", "fdr": 1.82e-27, "category": "Process"}, "top_terms": [{"term": "Immune system process", "fdr": 0.0, "cat": "Process"}, {"term": "Immune response", "fdr": 0.0, "cat": "Process"}, {"term": "Cytokine-mediated signaling pathway", "fdr": 0.0, "cat": "Process"}, {"term": "Cellular response to cytokine stimulus", "fdr": 0.0, "cat": "Process"}, {"term": "Response to organic substance", "fdr": 0.0, "cat": "Process"}]}}, "AGA": {"n_genes": 60, "ppi": {"n_genes": 60, "edges": 577, "expected": 211, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Response to growth factor", "fdr": 3.24e-08, "category": "Process"}, "top_terms": [{"term": "Regulation of cell death", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of programmed cell death", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of developmental process", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of apoptotic process", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of multicellular organismal process", "fdr": 0.0, "cat": "Process"}]}}, "CIA": {"n_genes": 60, "ppi": {"n_genes": 60, "edges": 572, "expected": 206, "p_value": 0.0}, "functional": {"label_matched": true, "matched": {"term": "Regulation of apoptotic process", "fdr": 9.23e-16, "category": "Process"}, "top_terms": [{"term": "Regulation of multicellular organismal development", "fdr": 0.0, "cat": "Process"}, {"term": "Gland development", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of epithelial cell proliferation", "fdr": 0.0, "cat": "Process"}, {"term": "Regulation of cell population proliferation", "fdr": 0.0, "cat": "Process"}, {"term": "Epithelium development", "fdr": 0.0, "cat": "Process"}]}}}, "pdb": {"n_proteins": 210, "with_experimental_pdb": 171, "fraction": 0.814, "total_pdb_structures": 5797}, "summary": {"axes_ppi_significant": 8, "axes_total": 8, "axes_label_matched": 8, "diseases_label_matched": 3}}