alopecia/data/twin_scenarios.json

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{"last_updated": "2026-05-30T19:19:20", "state_names": ["Wnt", "BMP", "SHH", "DP", "HFSC", "APO", "Hair"], "diseases": {"Healthy": {"label": "건강 모낭", "desc": "정상 모낭 항상성 기준선"}, "Androgenetic Alopecia": {"label": "남성형 탈모 (AGA)", "desc": "DHT 부하↑ → DKK1↑·IGF1↓ → 모낭 소형화"}, "Alopecia Areata": {"label": "원형 탈모 (AA)", "desc": "JAK-STAT/IFNγ 매개 면역 공격 → 모낭 정지"}, "Chemotherapy-induced Alopecia": {"label": "항암 유발 탈모 (CIA)", "desc": "화학요법 펄스 → p53 매개 모기질 apoptosis"}}, "interventions": {"none": {"label": "무처치", "genes": []}, "finasteride": {"label": "피나스테리드 (5AR2 억제)", "genes": ["SRD5A2", "AR"]}, "dutasteride": {"label": "두타스테리드 (이중 5AR)", "genes": ["SRD5A1", "SRD5A2"]}, "AR_antagonist": {"label": "AR 길항/siRNA (RU58841)", "genes": ["AR"]}, "minoxidil": {"label": "미녹시딜 (VEGF/K-ATP→DP, PGE2/Wnt)", "genes": ["VEGFA", "PDGFA"]}, "anti_DKK1": {"label": "항-DKK1 (Wnt 회복)", "genes": ["DKK1", "CTNNB1"]}, "wnt_agonist": {"label": "Wnt 작용제/발프로산", "genes": ["CTNNB1", "LRP6"]}, "JAK_inhibitor": {"label": "JAK 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