171 lines
4.2 KiB
JSON
171 lines
4.2 KiB
JSON
{
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"prediction_id": "AGA_synergy_brake_x_accelerator",
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"hypothesis": "AGA 에서 상류 'AR/5-ARI/BMP-antagonist'(Wnt 축 복원) × 하류 '미녹시딜/Wnt-agonist'(DP/anagen 부양) 병용은 Bliss 독립 기대를 초과하는 초가법적 시너지를 보인다 — Hair 산출 A 가 W·D 두 협동 문턱의 곱(AND-게이트)이기 때문.",
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"null_hypothesis": "두 팔은 서로 다른 경로이므로 효과는 가법적(Bliss 독립, 시너지초과=0).",
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"falsification": "실험 Bliss 초과량이 95% CI 내에서 ≤0 이면 A 의 협동적 AND-게이트 가정이 반증됨.",
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"headline": {
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"E_ref": 0.6,
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"synergy_excess_auc": 0.1225,
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"synergy_excess_peak": 0.1271,
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"combo_index_CI": 0.8136,
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"R1": 0.3863,
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"R2": 0.2416,
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"R_combo_actual": 0.657,
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"R_combo_bliss": 0.5346
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},
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"dose_curve": [
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{
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"E": 0.2,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 4.9209,
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"arm2_only": 4.7491,
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"combo": 5.0775,
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"healthy": 6.4826,
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"R1": 0.1721,
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"R2": 0.081,
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"R_combo": 0.2551,
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"bliss_expected": 0.2391,
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"synergy_excess": 0.016,
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"combo_index_CI": 0.9373
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},
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{
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"E": 0.3,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.0446,
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"arm2_only": 4.8254,
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"combo": 5.2847,
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"healthy": 6.4826,
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"R1": 0.2376,
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"R2": 0.1214,
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"R_combo": 0.365,
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"bliss_expected": 0.3302,
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"synergy_excess": 0.0347,
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"combo_index_CI": 0.9048
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},
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{
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"E": 0.4,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.1508,
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"arm2_only": 4.9014,
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"combo": 5.478,
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"healthy": 6.4826,
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"R1": 0.294,
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"R2": 0.1617,
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"R_combo": 0.4674,
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"bliss_expected": 0.4081,
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"synergy_excess": 0.0593,
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"combo_index_CI": 0.8732
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},
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{
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"E": 0.5,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.2433,
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"arm2_only": 4.977,
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"combo": 5.6609,
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"healthy": 6.4826,
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"R1": 0.343,
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"R2": 0.2018,
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"R_combo": 0.5644,
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"bliss_expected": 0.4756,
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"synergy_excess": 0.0888,
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"combo_index_CI": 0.8427
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},
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{
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"E": 0.6,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.325,
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"arm2_only": 5.052,
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"combo": 5.8356,
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"healthy": 6.4826,
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"R1": 0.3863,
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"R2": 0.2416,
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"R_combo": 0.657,
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"bliss_expected": 0.5346,
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"synergy_excess": 0.1225,
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"combo_index_CI": 0.8136
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},
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{
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"E": 0.7,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.3977,
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"arm2_only": 5.1265,
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"combo": 6.0041,
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"healthy": 6.4826,
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"R1": 0.4249,
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"R2": 0.2811,
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"R_combo": 0.7463,
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"bliss_expected": 0.5865,
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"synergy_excess": 0.1598,
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"combo_index_CI": 0.7859
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},
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{
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"E": 0.8,
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"metric": "auc",
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"untreated": 4.5963,
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"arm1_only": 5.4631,
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"arm2_only": 5.2005,
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"combo": 6.1674,
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"healthy": 6.4826,
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"R1": 0.4595,
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"R2": 0.3203,
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"R_combo": 0.8329,
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"bliss_expected": 0.6326,
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"synergy_excess": 0.2003,
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"combo_index_CI": 0.7595
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}
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],
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"threshold_sweep": [
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{
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"KDA": 0.2,
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"synergy_excess": 0.1098,
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"R_combo": 0.6472
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},
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{
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"KDA": 0.35,
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"synergy_excess": 0.1154,
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"R_combo": 0.6529
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},
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{
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"KDA": 0.5,
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"synergy_excess": 0.1225,
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"R_combo": 0.657
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},
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{
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"KDA": 0.65,
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"synergy_excess": 0.1309,
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"R_combo": 0.6588
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},
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{
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"KDA": 0.8,
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"synergy_excess": 0.1408,
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"R_combo": 0.6581
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},
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{
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"KDA": 1.0,
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"synergy_excess": 0.1561,
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"R_combo": 0.6534
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},
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{
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"KDA": 1.2,
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"synergy_excess": 0.1716,
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"R_combo": 0.6452
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},
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{
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"KDA": 1.5,
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"synergy_excess": 0.1596,
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"R_combo": 0.6439
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}
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],
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"threshold_peak_KDA": {
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"KDA": 1.2,
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"synergy_excess": 0.1716,
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"R_combo": 0.6452
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},
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"model_source": "follicle_cycle.py (8-state excitable ODE, COPASI-calibrated healthy cycle)"
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} |